Herein, we report the antioxidant activity of cannabidiol ( CBD) and Δ9-tetrahydrocannabinol (THC) in pure and mixed options at distinct ratios, as effectively as of six distinct Cannabis sativa extracts containing numerous proportions of CBD and THC by employing spectrophotometric (minimizing energy assay, two,2′-azino-bis(three-ethylbenzothiazoline-six-sulphonic acid) (ABTS), two,two-diphenyl-1-picrylhydrazyl (DPPH), hypochlorous acid (HOCl) scavenging assays) and electrochemical techniques (cyclic voltammetry and differential pulse voltammetry). The isolated cannabinoids, the distinct stoichiometric ratios of CBD and THC, and the all-natural extracts proved to have outstanding antioxidant properties in all the techniques employed in this operate. The antioxidant activity of CBD and THC was compared against that of the effectively-defined antioxidants such as ascorbic acid (AA), resveratrol (Resv) and (-)-epigallocatechin-three-gallate (EGCG). Clear proof of the synergistic and antagonistic effects among CBD and THC relating to to their antioxidant activities was observed. In addition, a great correlation was obtained among the optical and electrochemical techniques, which proved that the reported experimental procedures can conveniently be adapted to ascertain the antioxidant activity of extracts from numerous Cannabis sativa species and associated compounds.