Underneath present laws in Italy, Hashish for medical functions could also be administered orally within the type of decoction or Hashish oil extract. The scientific literature stories various preparation strategies, primarily for oils, however no research is offered that compares completely, from a technological viewpoint, the Hashish-based formulations presently administered to sufferers. With this in thoughts, this analysis work aimed to hold out particular formulation research to design commonplace working procedures for the preparation and optimization of Hashish-based galenic formulations. Each decoctions and oils had been ready underneath completely different working situations to establish essentially the most environment friendly course of for the manufacturing of formulations with a excessive focus of decarboxylated delta-9-tetrahydrocannabinol (THC) and cannabidiol ( CBD). Relating to Hashish oil, a brand new process has been developed that enables considerably larger restoration charges for THC and CBD in contrast with these for water-based extraction strategies (decoction) and people for oil-based strategies presently in use. Furthermore, primarily based on the outcomes, it’s potential to affirm that the prescription of Hashish-based decoctions shouldn’t be the advisable first-choice answer for remedy, contemplating the low focus of THC and CBD and, consequently, the excessive quantity of decoction that the affected person must ingest.