We performed a evaluate of systematic opinions (SRs) and randomized-controlled trials (RCTs) to investigate efficacy and security of cannabis-based medicine in sufferers with psychological issues. 5 knowledge bases have been systematically searched (2006-August 2018); four SRs (of 11 RCTs) and 14 RCTs (1629 individuals) have been included. Diagnoses have been: dementia, cannabis and opioid dependence, psychoses/schizophrenia, common social nervousness, posttraumatic stress dysfunction, anorexia nervosa, attention-deficit hyperactivity dysfunction, and Tourette`s dysfunction. Final result variables have been too heterogeneous to conduct a  meta-analysis. A story synthesis methodology was utilized. The examine high quality was assessed utilizing the risk-of-bias device and SIGN-checklists. THC- and CBD-based medicines, given as adjunct to pharmaco- and psychotherapy, have been related to enhancements of a number of signs of psychological issues, however not with remission. Uncomfortable side effects occurred, however extreme adversarial results have been talked about in single instances solely. To be able to present dependable remedy suggestions, extra and bigger RCTs with follow-up assessments, constant end result measures and energetic comparisons are wanted.