OBJECTIVE:

The aim of this assessment is to describe the historical improvement of investigation on cannabidiol.

Technique:

This assessment was carried out on reports drawn from Medline, Net of Science and SciELO.

DISCUSSION:

Soon after the elucidation of the chemical structure of cannabidiol in 1963, the initial research showed that cannabidiol was unable to mimic the effects of  Cannabis. In the 1970’s the quantity of publications on cannabidiol reached a 1st peak, possessing the investigation focused mostly on the interaction with delta9-THC and its antiepileptic and sedative effects. The following two decades showed reduced degree of interest, and the possible therapeutic properties of cannabidiol investigated had been mostly the anxiolytic, antipsychotic and on motor ailments effects. The final 5 years have shown a outstanding raise in publications on cannabidiol mostly stimulated by the discovery of its anti-inflammatory, anti-oxidative and neuroprotective effects. These research have recommended a wide variety of feasible therapeutic effects of cannabidiol on many situations, which includes Parkinson’s illness, Alzheimer’s illness, cerebral ischemia, diabetes, rheumatoid arthritis, other inflammatory ailments, nausea and cancer.

CONCLUSION:

In the final 45 years it has been feasible to demonstrate that CBD has a wide variety of pharmacological effects, lots of of which becoming of terrific therapeutic interest, but nonetheless waiting to be confirmed by clinical trials.