Cannabidiol ( CBD), the non-psychoactive element of Cannabis sativa, acts on a diverse choice of membrane proteins with promising therapeutic prospective in epilepsy and chronic discomfort. One particular such protein is the voltage-gated sodium channel (Nav). CBD shows a lack of specificity for sodium channels having said that, the approach of interaction is nonetheless unknown. In this evaluation, we will outline the research that report reproducible outcomes of CBD and other cannabinoids altering membrane channel function, with specific interest on Nav. Nav are implicated in fatal types of epilepsy and are also linked with chronic discomfort. This tends to make Nav prospective targets for CBD interaction because it has been reported to lower discomfort and seizures. One particular prospective approach of interaction that is of interest in this evaluation is no matter whether CBD impacts channel function by altering lipid bilayer properties, independent of any achievable direct interaction with membrane channels. CBD’s potential to interact with its targets is a novel and critical discovery. This discovery will not only prompt additional investigation towards CBD’s characterization, but also promotes the application of cannabinoids as potentially therapeutic compounds for illnesses like epilepsy and discomfort.