The endocannabinoid method is a complicated and almost ubiquitous network of endogenous ligands, enzymes, and receptors that can also be stimulated by exogenous compounds such as these derived from the marijuana plant, Cannabis sativa. Current information have shown that the endocannabinoid method is totally functional in the skin and is accountable for keeping lots of elements of skin homeostasis, such as proliferation, differentiation, and release of inflammatory mediators. Since of its function in regulating these crucial processes, the endocannabinoid method has been studied for its modulating effects on each inflammatory problems of the skin and skin cancer. Despite the fact that legal restrictions on marijuana as a Schedule I drug in the USA have produced studying cannabinoid compounds unfavorable, an growing quantity of research and clinical trials have focused on the therapeutic utilizes of cannabinoids. This assessment seeks to summarize the existing, and swiftly expanding field of investigation on the broad prospective utilizes of cannabinoids in inflammatory and neoplastic illnesses of the skin.