Marijuana has been proposed as therapy for a widening spectrum of healthcare conditions. Marijuana is a substance with lots of properties that may possibly be applicable to the management of amyotrophic lateral sclerosis (ALS). These incorporate analgesia, muscle relaxation, bronchodilation, saliva reduction, appetite stimulation, and sleep induction. In addition, marijuana has now been shown to have powerful antioxidative and neuroprotective effects, which may possibly prolong neuronal cell survival. In locations exactly where it is legal to do so, marijuana should be deemed in the pharmacological management of ALS. Additional investigation into the usefulness of marijuana in this setting is warranted.