Cannabidiol shows guarantee as a prospective remedy solution for alcohol use disorder, according to a new study published by the journal Alcoholism: Clinical and Experimental Investigation, and epublished by the U.S. National Institute of Well being.
“There is substantial interest in the therapeutic prospective of cannabidiol (CBD), a non-psychoactive cannabinoid found in plants of the genus Cannabis”, starts the abstract of the study. “The objective of the present systematic assessment was to characterize the current literature on this subject and to evaluate the credibility of CBD as a candidate pharmacotherapy for alcohol use disorder (AUD).”
Utilizing a complete search method, “303 special prospective articles have been identified and 12 in the end met criteria for inclusion (eight employing rodent models, three employing healthful adult volunteers, and 1 employing cell culture).” In each rodent and cell culture models, “CBD was discovered to exert a neuroprotective impact against adverse alcohol consequences on the hippocampus.” In rodent models, “CBD was discovered to attenuate alcohol-induced hepatotoxicity, particularly, alcohol-induced steatosis.”
Ultimately, “findings from preclinical rodent models also indicate that CBD attenuates cue-elicited and anxiety-elicited alcohol-in search of, alcohol self-administration, withdrawal-induced convulsions, and impulsive discounting of delayed rewards.”
In human research, “CBD was effectively tolerated and did not interact with the subjective effects of alcohol. ” Researchers state that “Collectively, provided its favorable effects on alcohol-connected harms and addiction phenotypes in preclinical models, CBD seems to have guarantee as a candidate AUD pharmacotherapy. This is additional bolstered by the absence of abuse liability and its common tolerability.”
The study concludes by stating that “Human preclinical and clinical research are required to decide whether or not these good effects in model systems substantively translate into clinically-relevant outcomes.”
Extra data on this study can be discovered by clicking right here.