Health-related cannabis a probable therapy for melanoma

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Abstract

OBJECTIVES:

Metastasis is the principal trigger of death in sufferers with melanoma. Cannabis-primarily based medicines are helpful adjunctive drugs in cancer patients. Tau and Stathmin proteins are the important proteins in cancer metastasis. Right here we have investigated the impact of a standardized Cannabis sativa extract on cell migration and Tau and Stathmin gene expression in the melanoma cell line.

Supplies AND Solutions:

In the therapy group, melanoma (B1617) was treated 48 hr with a variety of concentrations of standardized C. sativa extract. Cells with no therapy were regarded as the manage group, then study was followed by Quantitative RT-True Time PCR assay. Relative gene expression was calculated by the ΔΔct process. Migration assay was utilized to evaluate cancer metastasis.

Final results:

Tau and stathmin gene expression was drastically decreased compared to the manage group. Cell migration was also drastically decreased compared to controls.

CONCLUSION:

C. sativa decreased tau and stathmin gene expression and cancer metastasis. The final results might have some clinical relevance for the use of cannabis-primarily based medicines in sufferers with metastatic melanoma.

Copyright © 2018 Elsevier B.V. All rights reserved.

 

 

Supply:Pubmed

 

Vaseghi G1, Taki MJtwo, Javanmard SHtwo.

 

 

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