Cannabis sativa L. is possibly 1 of the oldest plants cultivated by man, but has remained a supply of controversy all through its history. No matter if pariah or panacea, this most versatile botanical has supplied a mirror to medicine and has pointed the way in the final two decades toward a host of healthcare challenges from analgesia to weight loss by means of the discovery of its myriad biochemical attributes and the endocannabinoid program wherein numerous of its elements operate. This study surveys the history of cannabis, its genetics and preparations. A assessment of cannabis usage in Ancient Egypt will serve as an archetype, whilst examining initially mentions from numerous Old Globe cultures and their pertinence for modern scientific investigation. Cannabis historians of the previous have supplied promising clues to possible treatment options for a wide array of at the moment puzzling healthcare syndromes like chronic discomfort, spasticity, cancer, seizure problems, nausea, anorexia, and infectious illness that stay challenges for 21st century medicine. Information and facts gleaned from the history of cannabis administration in its numerous types could deliver helpful points of departure for study into novel delivery strategies and standardization of cannabis-primarily based medicines that will permit their prescription for remedy of these intractable healthcare conditions.