Discomfort, spasticity, tremor, spasms, poor sleep top quality, and bladder and bowel dysfunction, amongst other symptoms, contribute considerably to the disability and impaired top quality of life of several sufferers with numerous sclerosis (MS). Motor symptoms referable to the basal ganglia, particularly paroxysmal dystonia, happen hardly ever and contribute to the encounter of distress. A substantial percentage of sufferers with MS report subjective advantage from what is usually illicit abuse of extracts of the Cannabis sativa plant the key cannabinoids include things like delta-9-tetrahydrocannabinol (delta9-THC) and cannabidiol. Clinical trials of cannabis plant extracts and synthetic delta9-THC deliver help for therapeutic advantage on at least some patient self-report measures. An illustrative case is presented of a 52-year-old lady with MS, paroxysmal dystonia, complicated vocal tics, and marijuana dependence. The patient was began on an empirical trial of dronabinol, an encapsulated kind of synthetic delta9-THC that is generally prescribed as an adjunctive medication for sufferers undergoing cancer chemotherapy. The patient reported a dramatic reduction of craving and illicit use she did not encounter the “high” on the prescribed medication. She also reported an improvement in the top quality of her sleep with diminished awakenings through the evening, decreased vocalizations, and the tension linked with their emission, decreased anxiousness and a decreased frequency of paroxysmal dystonia.